I'm not sure what you mean by "... something that will support squeezebox/VortexBox."
Do you mean something that runs Squeeze Server or something that runs softsqueeze? ie. A server or an audio player?
If you want the plug to decode/play audio, you will need to add a USB attached audio card or USB speakers. If you want the Plug to run Squeeze Server, it will do that; but, without the ability to trans-code. There are threads about both of these on this site if you search.
Since the Plug doesn't have video or graphics hardware built in, you pretty much need to use a USB attached graphics card. Some of the mini-monitors from Mimo have touch built in and have been used with a Plug. Search this site for DisplayLink and you should be able to find a few threads about this.
I have a Plug that uses a USB attached SSD and runs Squeeze Server 24/7. After initially struggling to get Squeeze Server installed, I haven't had any problems with this setup for ~10 months.
There is a package called SqueezePlug (http://squeezeplug.de/
) that is a version of Squeeze Server on Debian that can be loaded onto a Plug. I have not used it so have no direct experience with it.