Thank you for your replies.
Using Esata over usb is faster , but how many time do you want that sort of speed .
Well, I didn't tell the whole story

I'm going to use it as High Definition Storage where files might be around 1-8GB for 1 file. That's where speed matters unpacking RAR files and stream the stuff over the LAN.
I can access the hard drive at 50-60 megs Bytes / Sec if I`m doing a Md5 sum of any files on the drive
Are you talking about a USB or eSATA hard drive?
Too bad there's no real speed benefit for the eSATA. I guess I'll wait for the GuruPlug Benchmarks and reconsider my plans - although I think the speed result will be the same (since the hardware is almost the same).
And I have to give up my software encryption plans
